MSCs
围产期间充质干/基质细胞(MSCs)的生物学、技术和临床前动物研究
Mesenchymal Stem Cells in Clinical Trials for Immune Disorders. Glob Med Genet. 2024 Jun 27;11(3):196-199.
Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy. Elife. 2023 Sep 11;12:e84820.
Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1. Nat Commun. 2023 Jul 20;14(1):4373.
Superior protective effects of PGE2 priming mesenchymal stem cells against LPS-induced acute lung injury (ALI) through macrophage immunomodulation. Stem Cell Res Ther. 2023 Mar 22;14(1):48.
Off-the-shelf GMP-grade UC-MSCs as therapeutic drugs for the amelioration of CCl4-induced acute-on-chronic liver failure in NOD-SCID mice. Int Immunopharmacol. 2022 Dec;113(Pt A):109408.
Repair effect of photobiomodulation combined with human umbilical cord mesenchymal stem cells on rats with acute lung injury. J Photochem Photobiol B. 2022 Sep;234:112541.
Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection. Stem Cell Res Ther. 2022 Jun 17;13(1):253.
Human umbilical cord-derived mesenchymal stem cells treatment for refractory uveitis: a case series. Int J Ophthalmol. 2021 Nov 18;14(11):1784-1790. doi: 10.18240/ijo.2021.11.20. eCollection 2021.
Development and investigational new drug application of mesenchymal stem/stromal cells products in China. Stem Cells Transl Med. 2021 Nov;10 Suppl 2(Suppl 2):S18-S30.
Mesenchymal stem cell-derived extracellular vesicles attenuate radiation-induced lung injury via miRNA-214-3p. Antioxid Redox Signal. 2021 Oct 10;35(11):849-862. doi: 10.1089/ars.2019.7965. Epub
Therapeutic prospects of mesenchymal stem/stromal cells in COVID-19 associated pulmonary diseases: From bench to bedside. World J Stem Cells. 2021 Aug 26;13(8):1058-1071.
Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality. Stem Cell Res Ther. 2021 Jun 26;12(1):365.
Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts. Stem Cell Res Ther. 2021 Mar 20;12(1):196.
Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity. Stem Cell Res Ther. 2021 Feb 17;12(1):138.
The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 2021 Jan 22;12(1):77. doi: 10.1186/s13287-021-02156-5.
Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel. Cell Biosci. 2021 Jan 6;11(1):6.
The Promise of Mesenchymal Stem Cells Therapy for Acute Respiratory Distress Syndrome Caused by COVID-19. Curr Stem Cell Res Ther. 2021;16(3):277-285.
Spatio-Temporal Metabolokinetics and Efficacy of Human Placenta-Derived Mesenchymal Stem/Stromal Cells on Mice with Refractory Crohn's-like Enterocutaneous Fistula. Stem Cell Rev Rep. 2020 Dec;16(6):1292-1304.
Extracellular vesicles derived from human placental mesenchymal stem cells alleviate experimental colitis in mice by inhibiting inflammation and oxidative stress. Int J Mol Med. 2020 Oct;46(4):1551-1561.
A nitric oxide-releasing hydrogel for enhancing the therapeutic effects of mesenchymal stem cell therapy for hindlimb ischemia. Acta Biomater. 2020 Sep 1;113:289-304. doi: 10.1016/j.actbio.2020.07.011.
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment. J Biol Chem. 2020 Aug 21;295(34):12203-12213.
High-efficient generation of VCAM-1+mesenchymal stem cells with multidimensional superiorities in signatures and efficacy on aplastic anaemia mice. Cell Prolif. 2020 Aug;53(8):e12862. doi: 10.1111/cpr.12862.
IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics. 2020 Jun 19;10(17):7697-7709. doi: 10.7150/thno.45434. eCollection 2020.
Enhanced therapeutic effects of MSC-derived extracellular vesicles with an injectable collagen matrix for experimental acute kidney injury treatment. Stem Cell Res Ther. 2020 Apr 22;11(1):161.
Mesenchymal stem cell-derived extracellular vesicles for corneal wound repair. Stem Cells Int. 2019 Dec 9;2019:5738510.
Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease. Stem Cell Res Ther. 2019 Nov 28;10(1):354. doi: 10.1186/s13287-019-1478-4.
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. Theranostics. 2019 Sep 21;9(23):6976-6990.
Comparison of the biological functions between human bone marrow derived CD106 (+)Mesenchymal stem cells and CD106 (-) subgroup. Acta Academiae Medicinae Sinicae. 2019, 30;41(4):443-451. doi: 10.3881/j.issn.1000-503X.10887.
JNKi- and DAC-programmed mesenchymal stem/stromal cells from hESCs facilitate hematopoiesis and alleviate hind limb ischemia. Stem Cell Res Ther. 2019 Jun 24;10(1):186. doi: 10.1186/s13287-019-1302-1.
IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia. Stem Cell Res Ther. 2019 Apr 29;10(1):129. doi: 10.1186/s13287-019-1230-0.
Heterogeneity of Human Mesenchymal Stromal/Stem Cells. Adv Exp Med Biol. 2019;1123:165-177. doi: 10.1007/978-3-030-11096-3_10.
Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30081-30091.
Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction. Stem Cell Res Ther. 2018 May 11;9(1):129.
Effect of CD106(+) Mesenchymal Stem Cell on Bone Marrow Vascular Failure in Patients with Aplastic Anemia. Acta Academiae Medicinae Scincae. 2018 Apr 28;40(2):178-186. doi: 10.3881/j.issn.1000-503X.2018.02.007.
Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway. Cytotherapy. 2018 Feb;20(2):181-188.
Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4(+) T cells. Exp Ther Med. 2017 Oct;14(4):3541-3548.
CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF-kappaB in the bone marrow failure of acquired aplastic anemia. Stem Cell Res Ther. 2017 Aug 1;8(1):178.
Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017,133:70-81. doi: 10.1016/j.biomaterials.2017.04.030.
Knockdown of IL-8 provoked premature senescence of placenta-derived mesenchymal stem cells. Stem Cells Dev. 2017 Jun 15;26(12):912-931.
New insights into the heterogeneity and functional diversity of human mesenchymal stem cells. Biomed Mater Eng. 2017;28(s1):S29-S45. doi: 10.3233/BME-171622. PMID: 28372276
Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta. Stem Cell Res Ther. 2016 Nov 10;7(1):163.
Interferon-gamma alters the microRNA profile of umbilical cord-derived mesenchymal stem cells. Mol Med Rep. 2016 Nov;14(5):4187-4197.
Mesenchymal stem cells derived from human bone marrow and adipose tissue maintain their immunosuppressive properties after chondrogenic differentiation: role of HLA-G. Stem Cells Dev. 2016 Oct 1;25(19):1454-69. doi: 10.1089/scd.2016.0022.
Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury. Cell Death Dis. 2016 ;7(9):e2387. doi: 10.1038/cddis.2016.276.
VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity. Stem Cell Res Ther. 2016 Apr 4;7:49. doi: 10.1186/s13287-016-0297-0.
Human umbilical ord-derived mesenchymal stem cells secrete interleukin-6 to influence differentiation of leukemic cells. Acta Academiae Medicinae Scincae. 2016 Apr;38(2):164-8.
Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension. Exp Ther Med. 2016 Feb;11(2):467-475.
Stem cells and vascular regenerative medicine: A mini review. Clin Hemorheol Microcirc. 2016;64(4):613-633. doi: 10.3233/CH-168036.
Proangiogenic features of mesenchymal stem cells and their therapeutic applications. Stem Cells Int. 2016;2016:1314709. doi: 10.1155/2016/1314709.
Mesenchymal stem cells suppress CaN/NFAT expression in the pulmonary arteries of rats with pulmonary hypertension. Exp Ther Med. 2015;10(5):1657-1664.
Label-free assessment of replicative senescence in mesenchymal stem cells by Raman microspectroscopy. Biomed Opt Express. 2015 Oct 21;6(11):4493-500. doi: 10.1364/BOE.6.004493. eCollection
High oncentrations of TNF-alpha induce cell death during interactions between human umbilical cord mesenchymal stem cells and peripheral blood mononuclear cells. PLoS One. 2015 May 29;10(5):e0128647. doi: 10.1371/journal.pone.0128647.
Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway. Cell Physiol Biochem. 2015;36(5):1991-2002. doi: 10.1159/000430167.
Human umbilical cord mesenchymal stem cells promote breast cancer metastasis by interleukin-8- and interleukin-6-dependent induction of CD44(+)/CD24(-) cells. Cell Transplant. 2015;24(12):2585-99. doi: 10.3727/096368915X687462.
Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice. Int J Biochem Cell Biol. 2014 Aug;53:372-9. doi: 10.1016/j.biocel.2014.06.003.
Biological characteristics of exosomes secreted by human bone marrow mesenchymal stem cells. Chin J Exp Hemat. 2014 Jun;22(3):595-9.
Adipogenic potentials of mesenchymal stem cells from human bone marrow, umbilical cord and adipose tissue are different. Chin J Exp Hemat. 2014 Jun;22(3):588-94.
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy. Biomaterials. 2014 Jun;35(19):5162-70.
Programming of the development of tumor-promoting neutrophils by mesenchymal stromal cells. Cell Physiol Biochem. 2014;33(6):1802-14. doi: 10.1159/000362959.
Decreased intracellular pH induced by cariporide differentially contributes to human umbilical cord-derived mesenchymal stem cells differentiation. Cell Physiol Biochem. 2014;33(1):185-94.
Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation. Cell Death Dis. 2013 Dec 5;4(12):e950. doi: 10.1038/cddis.2013.480.
The expression and role of miR-301a in human umbilical cord-derived mesenchymal stromal cells. Cytotherapy. 2013 Dec;15(12):1511-6. doi: 10.1016/j.jcyt.2013.06.007.
IL-1beta promotes the hematopoietic support of human umbilical cord mesenchymal stem cells. Chinese J Exp Hemat. 2013 Aug;21(4):1005-9. doi: 10.7534/j.issn.1009-2137.2013.04.037. PMID: 23998602 Chinese.
The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis. Clin Exp Immunol. 2013 Jul;173(1):28-37. doi: 10.1111/cei.12080.
Mesenchymal stem cells induce granulocytic differentiation of acute promyelocytic leukemic cells via IL-6 and MEK/ERK pathways. Stem Cells Dev. 2013 Jul 1;22(13):1955-67. doi: 10.1089/scd.2012.0621.
Expression and role of Toll-like receptors on human umbilical cord mesenchymal stem cells. Cytotherapy, 15(4):423-33, 2013.
CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One, 2013;8(3):e59354. doi: 10.1371
Effects of human umbilical cord-derived mesenchymal stem cells on anterior chamber-associated immune deviation. Int Immunopharmacol. ,15(1):114-20,2013
Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia. PLoS One, 2012;7(11):e47764. doi: 10.1371/journal.pone.0047764.
Effects of human umbilical cord-derived mesenchymal stem cells on anterior chamber-associated immune deviation. Int Immunopharmacol. 15(1):114-20, 2013.
Cell delivery in cardiac regenerative therapy. Ageing Res Rev, 211:32-40,2012
Cardiac cell therapy: pre-conditioning effects in cell-delivery strategies. Cytotherapy., 14(3):260-6,2012
IL-6 production stimulated by CD14+ monocytes-paracrined IL-1β does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells. Cell Physiol Biochem, 2:551-560, 2012
A Toxicity Study of Multiple-administration Human Umbilical Cord Mesenchymal Stem Cells in Cynomolgus Monkeys. Stem Cell & Dev., 21(9): 1401-1408, 2012
Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model. Exp Eye Res. 102:44-9, 2012
Wang Y, Han ZB, Song YP, Han ZC. Safety of mesenchymal stem cells for clinical application. Stem Cells Int. 2012; 2012:652034.
Human perinatal stem cell banking: experiences and perspectives for regenerative medicine. Science (suppl), p20, 2012
Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4+ T cells in aplastic anemia. Results in Immunol, 2012; 2:142-147.
Mesenchymal Stem Cells Support Proliferation and Terminal Differentiation of B Cells. Cell Physiol Biochem, 30(6):1526-1537,2012
Retrograde delivery of stem cells: promising delivery strategy for myocardial regenerative therapy. Clin Transplant. 2011 Sep 15. doi: 10.1111/j.1399-0012.2011.01508.x
Detecting viability transitions of umbilical cord mesenchymal stem cells by Raman micro-spectroscopy. Laser Phys Lett, 8:78-84, 2011
Relations between reactive oxygen species and Raman spectral variations of human umbilical cord mesenchymal stem cells with different viability. Laser Physics, 21:1-8, 2011
Umbilical cord mesenchymal stem cells ameliorate TNBS-induced colitis. Cell Transplant, 2011 Mar 9.
Mesenchymal stem cells ameliorate experimental autoimmune uveoretinitis by comprehensive modulation of systemic autoimmunity. Invest Ophthalmol Vis Sci. 16;52(6):3143-52, 2011
Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+CD25+forkhead boxp3 (FOXP3)+regulatory T cells and balancing anti- and pro-inflammatory factors. Cell Physiol Biochem, 27:587-596,2011
p38 MAPK constributes to the growth inhibition of leukemic tumor cells mediated by human umbilical cord mesenchymal stem cells. Cell Physiol Biochem, 26(6):799-808, 2010
Intravenous administration of bone marrow mesenchymal stem cells benefits experimental autoimmune myasthenia gravis mice through an immunomodulatory action. Scand J Immunol. 72(3):242-9, 2010.
Mesenchymal stem cells from bone marrow show a stronger stimulating effect on megakaryocyte progenitor expansion than those from non-hematopoietic tissues. Platelets, 21(3):199-210, 2010
CD14(+) Monocytes promote the immunosuppressive effect of human umbilical cord matrix stem cells. Exp Cell Res. 2010 Apr 23.
No contribution of umbilical cord mesenchymal stromal cells to capillarization and venularization of hepatic sinusoids accompanied by hepatic differentiation in carbon tetrachloride-induced mouse liver fibrosis. Cytotherapy. 12(3):371-83, 2010
Human umbilical cord mesenchymal stem cells (UC-MSCs)exert immunosuppressive activities through a PGE2-dependent mechanism. Clin Immunol, 2010 Mars 4
Therapeutic effect of human umbilical cord multipotent mesenchymal stem cells in a rat model of stroke. Transplantation, 15;87(3):350-9, 2009
Neural ganglioside GD2 identifies a subpopulation of MSC in human umbilical cord. Cell Physiol Biochem, 23:415-24,2009
Differentiation of Human umbilical cord mesenchymal stem cells into low immunogenic hepatocyte-like cells. Cytotherapy, 9:1-13, 2009
Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: implication in the migration. Proteomics, 9(1):20-30, 2009
Cardiac potential of stem cells from whole human umbilical cord tissue. J Cell Biochem, 2009 May 20.
Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of anti-inflammation and angiogenesis. Cell Physiol Biochem, 24(3-4):307-16, 2009.
Biology and clinical potential in Type 1 Diabetes Therapy. J Cell Mol Med, 12 :1155-68, 2008
Stem cells for tissue engineering of myocardial constructs. Ageing Res Rev. , 6:289-301, 2007
Therapeutic potential of human umbilical cord-derived stem cells in ischemic diseases. Transplant Proc. , 39:1620-2, 2007
In vitro and in vivo differentiation of human umbilical cord derived stem cells into endothelial cells. J Cell Biochem, 100:608-16, 2007
Human umbilical cord derived stem cells for the injured heart. Med Hypotheses, 68:94-7, 2007
Therapeutic potential of human umbilical cord derived stem cells in a rat myocardial infarction model. Ann Thorac Surg.,83:1491-8, 2007
Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica, 91(8):1017-26, 2006
Application of stem cells for cardiovascular grafts tissue engineering. Transpl Immunol, 16(1):1-7, 2006
Mesenchymal stem/stromal cells (MSC) transfected with stromal derived factor 1 (SDF-1) for therapeutic neovascularization : Enhancement of cell recruitment and entrepment. Med Hypotheses 67:1308-12,2006
Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun, 347:12-21, 2006
Cellular therapy and myocardial tissue engineering: the role of adult stem and progenitor cells. Eur J Cardiothorac Surg. 30:770-81, 2006
Characterization and neural differentiation of fetal lung mesenchymal stem cells. Cell Transplant, 14(5):311-21, 2005.
Other Stem Cells
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Biology and technology of other stem cells
iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review. Stem Cell Res Ther. 2024 Jun 26;15(1):185.
Combined lineage tracing and scRNA-seq reveal the activation of Sox9+ cells in renal regeneration with PGE2 treatment. Cell Prolif. 2024 May 27:e13679. doi: 10.1111/cpr.13679.
Association of iKIR-mismatch model and donor aKIRs with better outcome in haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia. Front Immunol. 2023 Jan 24;13:1091188. doi: 10.3389/fimmu.2022.1091188. eCollection 2022.
Renal endothelial cell-targeted extracellular vesicles protect the kidney from ischemic Injury. Adv Sci (Weinh). 2023,10(3):e2204626. doi: 10.1002/advs.202204626.
Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood. Am J Cancer Res. 2022 May 15;12(5):2132-2145. eCollection 2022. PMID: 35693070 Free PMC article.
CAR-NK cells for cancer immunotherapy: from bench to bedside. Biomark Res. 2022 Mar 18;10(1):12. doi: 10.1186/s40364-022-00364-6
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice. Bioact Mater. 2023 Jul 1;29:85-97. doi: 10.1016/j.bioactmat.2023.06.011. eCollection 2023 Nov
The sustained PGE2 release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model. J Nanobiotechnology. 2022 Feb 24;20(1):95. doi: 10.1186/s12951-022-01301-3.
Renal subcapsular delivery of PGE(2) promotes kidney repair by activating endogenous Sox9(+) stem cells. iScience. 2021 Oct 8;24(11):103243. doi: 10.1016/j.isci.2021.103243. eCollection 2021.
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury. Stem Cell Res Ther. 2021 Jul 2;12(1):379. doi: 10.1186/s13287-021-02460-0
Natural killer cells: of-the-shelf cytotherapy for cancer immunosurveillance. Am J Cancer Res. 2021 Apr 15;11(4):1770-1791. eCollection 2021.
Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing. Acta Biomater. 2021 Mar 1;122:199-210. doi: 10.1016/j.actbio.2020.12.055.
Multifaceted modifications for a cell size-based circulating tumor cell scope technique hold the prospect for large-scale application in general populations. Cell Biol Int. 2021 Feb;45(2):345-357. doi: 10.1002/cbin.11491.
High-efficient generation of natural killer cells from peripheral blood with preferable cell vitality and enhanced cytotoxicity by combination of IL-2, IL-15 and IL-18. Biochem Biophys Res Commun. 2021 Jan 1;534:149-156. doi: 10.1016/j.bbrc.2020.12.012.
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment. J Biol Chem. 2020 Aug 21;295(34):12203-12213. doi: 10.1074/jbc.RA120.012732.
Human supernumerary teeth-derived apical papillary stem cells possess preferable characteristics and efficacy on hepatic fibrosis in mice. Stem Cells Int. 2020 Jan 30;2020:6489396. doi: 10.1155/2020/6489396. eCollection 2020
Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization. Theranostics. 2018 Oct 22;8(19):5348-5361. doi: 10.7150/thno.27385. eCollection 2018.
Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging. Stem Cells Int. 2018 Mar 25;2018:7906531. doi: 10.1155/2018/7906531. eCollection 2018
VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway. Biomaterials. 2018 Mar;158:34-43. doi: 10.1016/j.biomaterials.2017.12.014.
Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec;23(12):1488-1498. doi: 10.1038/nm.4437.
Nitric oxide releasing hydrogel promotes endothelial differentiation of mouse embryonic stem cells. Acta Biomater. 2017 Nov;63:190-199. doi: 10.1016/j.actbio.2017.08.037.
Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model. Cell Physiol Biochem. 2017;42(1):407-415. doi: 10.1159/000477485. Epub 2017 May 25
Extracellular matrix can recover the downregulation of adhesion molecules after cell detachment and enhance endothelial cell engraftment. Sci Rep. 2015 Jun 3;5:10902. doi: 10.1038/srep10902.
Bone marrow is a reservoir for cardiac resident stem cells. Sci Rep. 2016 Jun 27;6:28739. doi: 10.1038/srep28739.
Gene and microRNA profiling of human induced pluripotent stem cell-derived endothelial cells. Stem Cell Rev Rep. 2015 Apr;11(2):219-27. doi: 10.1007/s12015-014-9582-4
Bioluminescence imaging of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction. Methods Mol Biol. 2013;1052:203-15. doi: 10.1007/7651_2013_15.
Human embryonic stem cell-derived endothelial cells as cellular delivery vehicles for treatment of metastatic breast cancer. Cell Transplant. 2013;22(11):2079-90. doi: 10.3727/096368912X657927.
Method of expansion of late endothelial progenitor cells. Chin J Med. 2012 Sep 25;92(36):2574-7.
Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury. BMC Nephrol. 2012 Sep 10;13:105. doi: 10.1186/1471-2369-13-105.
Establishment of a new method to induce the differentiation of embryonic pancreatic cells into mature endocrine cells.Acta Academiae Mediciniae Siniae. 2012 Aug;34(4):343-7. doi: 10.3881/
Identification, characterization and biological significance of very small embryonic-like stem cells (VSELs) in regenerative medicine. Histol Histopathol. 2012 Jul;27(7):827-33. doi: 10.14670/HH-27.827.
CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. Biomaterials. 2012 Jul;33(20):5107-14. doi: 10.1016/j.biomaterials.2012.03.067.
Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. J Cell Biochem. 2011 Mar;112(3):840-8. doi: 10.1002/jcb.22982.
Isolation of pancreatic progenitor cells with the surface marker of hematopoietic stem cells. Int J Endocrinol. 2012;2012:948683. doi: 10.1155/2012/948683. Epub 2012 Dec 20
Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition. J Cell Biochem. 2009 Apr 15;106(6):1041-7. doi: 10.1002/jcb.22082.
Stem/progenitor cells in liver injury repair and regeneration. Biol Cell. 2009 Jul 31;101(10):557-71. doi: 10.1042/BC200801
Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL. Acta Pharmacol Sin. 2009 May;30(5):545-52. doi: 10.1038/aps.2009.41.
Endothelial progenitor cell therapy in atherosclerosis: a double-edged sword? Ageing Res Rev. 2009 Apr;8(2):83-93. doi: 10.1016/j.arr.2008.11.002
Abnormal immunity and stem/progenitor cells in acquired aplastic anemia. Crit Rev Oncol Hematol. 2010 Aug;75(2):79-93. doi: 10.1016/j.critrevonc.2009.12.001.
Suppression of ABCG2 inhibits cancer cell proliferation. Int J Cancer. 2010 Feb 15;126(4):841-51. doi: 10.1002/ijc.24796.
Ex vivo expansion of megakaryocyte progenitors from human umbilical cord blood CD34(+) cells. Chin J Exp Hematol. 2008 Oct;16(5):1121-5
Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis. 2008 Oct;29(10):1853-61. doi: 10.1093/carcin/bgn066. Epub 2008 Mar 13.
Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation. J Cell Biochem. 2008 Aug 15;104(6):2348-62. doi: 10.1002/jcb.21795.
Hemangiopoietin supports animal survival and accelerates hematopoietic recovery of chemotherapy-suppressed mice. Eur J Haematol. 2007 Dec;79(6):477-85. doi: 10.1111/j.1600-0609.2007.00969.x.
Enhancement of neovascularization with mobilized blood cells Transplantaion: supply of angioblasts and angiogenic cytokines. J Cell Biochem. 2007 Sep 1;102(1):183-95. doi: 10.1002/jcb.21290.
Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives. Histol Histopathol. 2007 Jun;22(6):677-86. doi: 10.14670/HH-22.677.
Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007 May;211(2):279-86. doi: 10.1002/jcp.20978.
Neovascularization potential of mobilized peripheral mononuclear cells from diabetes patients. Acta Academiae Midiciniae Siniae, 2007 Apr;29(2):262-7. PMID: 17536281 Chinese.
The therapeutic efficacy for limb ischemia by transplantation of mobilized peripheral blood cells before and after CD34+ cell depletion. Chin J Hematol. 2007 Mar;28(3):194-8.
Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells. J Lipid Res. 2007 Mar;48(3):518-27. doi: 10.1194/jlr.M600251-JLR200.
Prevention of diabetic microangiopathy by prophylactic transplant of mobilized peripheral blood mononuclear cells. Acta Pharmacol Sin. 2007 Jan;28(1):89-97. doi: 10.1111/j.1745-7254.2007.00476.
Leukemia stem cells. Int J Hematol. 2006 Aug;84(2):123-7. doi: 10.1532/IJH97.A10503.
Live attenuated Salmonella carrying platelet factor 4 cDNAs as radioprotectors. Radiat Res. 2006 Aug;166(2):352-9. doi: 10.1667/RR3603.1
Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase. J Lipid Res. 2006 Jun;47(6):1227-37. doi: 10.1194/jlr.M500507-JLR200. Epub 2006 Mar
G-CSF-mobilized peripheral blood mononuclear cells from diabetic patients augment neovascularization in ischemic limbs but with impaired capability. J Thromb Haemost. 2006 May;4(5):993-1002. doi: 10.1111/j.1538-7836.2006.01906
Matrix metalloproteinases in bone marrow: roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies. Histol Histopathol. 2006 May;21(5):519-31. doi: 10.14670/HH-21.519.
Therapeutic neovascularization by transplantation of mobilized peripheral blood mononuclear cells for limb ischemia. A comparison between CD34+ and CD34- mononuclear cells. Thromb Haemost. 2006 Feb;95(2):301-11. doi: 10.1160/TH05-06-0442.
Endothelial progenitor cells transfected with PDGF: cellular and molecular targets for prevention of diabetic microangiopathy. Med Hypotheses. 2006;67(6):1308-12. doi: 10.1016/j.mehy.2006.05.033.
Transplantation of umbilical cord blood-derived endothelial progenitor cells: a promising method of therapeutic revascularisation. Eur J Haematol. 2006 Jan;76(1):1-8. doi: 10.1111/j.1600-0609.2005.00579
Vascular differentiation of hematopoietic stem cells and possible application in the treatment of limb ischemic diseases. Acta Academiae Mediciae Siniae. 2005 Dec;27(6):782-5
An effective and simple expansion system for megakaryocyte progenitor cells using a combination of heparin with thrombopoietin and interleukin-11. Exp Hematol. 2005 Dec;33(12):1537-43. doi: 10.1016/j.exphem.2005.08.010
Enhanced growth suppression of Philadephia1 leukemia cells by targeting bcr3/abl2 and VEGF through antisense strategy. Leukemia. 2005 Sep;19(9):1517-24. doi: 10.1038/sj.leu.2403851
Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation. J Cell Biochem. 2005 Jun 1;95(3):559-70. doi: 10.1002/jcb.20436
Intra-bone marrow cavity transplantation of human umbilical cord blood mononuclear cells into NOD/SCID mice. Chin J Hematol. 2005 May;26(5):261-4
In vitro vasculogenesis and angiogenesis of mouse embryonic stem cells. Acta Acadeniae Mediciae Siniae, 2005 Feb;27(1):62-6.
Bone marrow stromal cells transduced with human hemangiopoietin gene support hematopoiesis in vitro. Haematologica. 2005 Feb;90(2):157-65.
Statins, nitric oxide and neovascularization. Cardiovasc Drug Rev. 2005 Winter;23(4):281-92. doi: 10.1111/j.1527-3466.2005.tb001
Akt signaling and its role in postnatal neovascularization. Histol Histopathol. 2005 Jan;20(1):275-81. doi: 10.14670/HH-20.275.
Stem cell factor improves SCID-repopulating activity of human umbilical cord blood-derived hematopoietic stem/progenitor cells in xenotransplanted NOD/SCID mouse model. Bone Marrow Transplant. 2005 Jan;35(2):137-42. doi: 10.1038/sj.bmt.1704751.
Differential expression of a homing-related molecule repertoire among umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cell Chin J Hematol. 2004 Dec;25(12):736-9. PMID: 15730718 Chinese.
Early down-regulation of Bcl-xL expression during megakaryocytic differentiation of thrombopoietin-induced CD34+ bone marrow cells in essential thrombocythemia. Haematologica. 2004 Oct;89(10):1199-206.
Signalling mechanisms of anoikis. Histol Histopathol. 2004 Jul;19(3):973-83. doi: 10.14670/HH-19.973
Phosphatidylinositide 3-kinase/AKT in radiation responses. Histol Histopathol. 2004 Jul;19(3):915-23. doi: 10.14670/HH-19.915.
Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood. 2004 Jun 15;103(12):4449-56. doi: 10.1182/blood-2003-06-1825.
Enhancement of neovascularization with cord blood CD133+ cell-derived endothelial progenitor cell transplantation. Thromb Haemost. 2004 Jun;91(6):1202-12. doi: 10.1160/TH03-06-0378
Platelet factor 4 enhances the adhesion of normal and leukemic hematopoietic stem/progenitor cells to endothelial cells. Leuk Res. 2004 Jun;28(6):631-8.
Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through phosphatidylinositol 3-kinase-AKT pathway. Biochem Biophys Res Commun. 2004 Apr 23;317(1):198-204.
Short-term ex vivo expansion sustains the homing-related properties of umbilical cord blood hematopoietic stem and progenitor cells. Haematologica. 2004;89(3):265-73.
Transplantation of human umbilical cord stem cells improves neurological function recovery after spinal cord injury in rats. Acta Academiae Mediciae Siniae, 2004 Feb;26(1):38-42.
A single chain antibody obtained by cell panning of antibody phage inhibits homoaggregation of human leukemia cells. Hum Antibodies. 2004;13(4):111-8
Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant. 2004;13(2):113-22.
Transplantation of cord blood endothelial progenitor cells ameliorates limb ischemia. Chin J Med. 2003 Aug 25;83(16):1437-41.
The effects of the short-term ex vivo expansion on the adhesion characteristics and chemotactic function of expanded ex vivo CD34(+) cells. Chin J Med,. 2003 Jul 25;83(14):1262-5.
The effects of cytokines mediated ex vivo expansion on the cell adhesion molecule expression of cord blood hematopoietic stem and progenitor cells. Acta Academiae Mediciae Siniae, 2002 Feb;24(1):7-10.
The impact of hepatitis B virus infected patients or donors on the outcome of hematopoietic stem cell transplantation. Chin J Hematol, 2000 Aug;21(8):414-6
Ex vivo expansion of megakaryocytic cells. Int J Hematol. 2000 Apr;71(3):203-10.
EVs
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Biology, technology and preclinical animal studies of MSCs derived extracellular vesicles (EVs)
Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases. Cell Commun Signal. 2024;22(1):6. doi: 10.1186/s12964-023-01369-w.
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice. Bioact Mater. 2023 Jul 1;29:85-97. doi: 10.1016/j.bioactmat.2023.06.011. eCollection 2023
Renal Endothelial Cell-Targeted Extracellular Vesicles Protect the Kidney from Ischemic Injury. Adv Sci (Weinh). 2023;10(3):e2204626. doi: 10.1002/advs.202204626
Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection. Stem Cell Res Ther. 2022 Jun 17;13(1):253. doi: 10.1186/s13287-022-02922-z.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Radiation-Induced Lung Injury via miRNA-214-3p. Antioxid Redox Signal. 2021 Oct 10;35(11):849-862.
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury. Stem Cell Res Ther. 2021 Jul 2;12(1):379. doi: 10.1186/s13287-021-02460-0. PMID: 34215331 Free PMC article.
Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts. Stem Cell Res Ther. 2021 Mar 20;12(1):196. doi: 10.1186/s13287-021-02262-4.
The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 2021 Jan 22;12(1):77. doi: 10.1186/s13287-021-02156-5.
Extracellular vesicles derived from human placental mesenchymal stem cells alleviate experimental colitis in mice by inhibiting inflammation and oxidative stress. Int J Mol Med. 2020 Oct; 46:1551-1561.
In vivo two-photon microscopy reveals the contribution of Sox9(+) cell to kidney regeneration in a mouse model with extracellular vesicle treatment. J Biol Chem. 2020 Aug 21;295(34):12203-12213. doi: 10.1074/jbc.RA120.012732. Epub 2020 Jul 8.
Enhanced therapeutic effects of MSC-derived extracellular vesicles with an injectable collagen matrix for experimental acute kidney injury treatment. Stem Cell Res Ther. 2020 Apr 22;11(1):161.
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Corneal Wound Repair. Stem Cells Int. 2019 Dec 9;2019:5738510. doi: 10.1155/2019/5738510. eCollection 2019.
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. Theranostics. 2019 Sep 21;9(23):6976-6990. doi: 10.7150/thno.35305. eCollection 2019.
Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30081-30091
Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway. Cytotherapy. 2018 Feb;20(2):181-188. doi: 10.1016/j.jcyt.2017.11.006.
Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017 Jul;133:70-81. doi: 10.1016/j.biomaterials.2017.04.030.
Biological characteristics of exosomes secreted by human bone marrow mesenchymal stem cells. Chinese J Exp Hemat. 2014 Jun;22(3):595-9. doi: 10.7534/j.issn.1009-2137.2014.03.004.
Mesenchymal Stem Cells
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Mesenchymal stem/stromal cells
Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial. Signal Transduct Target Ther. 2024 Apr 23;9(1):102. doi: 10.1038/s41392-024-01793-5. Clinical Trial.
Human umbilical cord-derived mesenchymal stem cells treatment for refractory uveitis: a case series. Int J Ophthalmol. 2021 Nov 18;14(11):1784-1790. doi: 10.18240/ijo.2021.11.20. eCollection 2021.
Safety and Efficacy of Placenta-Derived Mesenchymal Stem Cell Treatment for Diabetic Patients with Critical Limb Ischemia: A Pilot Study. Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):542-548.
Successful treatment of a 19-Month-Old boy with hepatitis sssociated splastic anemia by infusion of umbilical cord-derived mesenchymal stromal cells: A case report. Cell Transplant, 30:1-6,2021
Combination of umbilical cord mesenchymal stem cells and standard immunosuppressive regimen for pediatric patients with severe aplastic anemia. BMC Pediatr. 2021 Feb 27;21(1):102. doi: 10.1186/s12887-021-02562-x. PMID: 33639900, Clinical Trial.
Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial. Stem Cell Res Ther. 2020 ;11(1):244. doi: 10.1186/s13287-020-01695-7. PMID: 32586366,Clinical Trial.,
Three-week topical treatment with placenta-derived mesenchymal stem cells hydrogel in a patient with diabetic foot ulcer. A case report. Medicine (Baltimore). 2019 Mar;98(10):e14869.
Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study. CNS Neurosci Ther. 2016 Aug;22(8):677-85. doi: 10.1111/cns.12559. Epub 2016 May 24.
Reduced intensity conditioning, combined transplantation of haploidentical hematopoietic stem cells and mesenchymal stem cells in patients with severe aplastic anemia. PLoS One. 2014 Mar 3;9(3):e89666. doi: 10.1371/journal.pone.0089666. eCollection 2014.
Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD. Stem Cell Res. 2014 Jan;12(1):132-8. doi: 10.1016/j.scr.2013.10.001.
Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells with a myeloablative regimen for refractory/relapsed hematologic malignancy. Ann Hematol, 2013 July 11
Safety of mesenchymal stem cells for clinical application. Stem Cells Int. 2012; 2012:652034.
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med, 51(1):94-100, 2011
Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis. Mult Scler. 15:644-6,2009
Treatment of refractory systemic sclerosis with human umbilical cord mesenchymal stem cell transplantation. Cell Res 2008,18:71; published online 4 August 200
Other Stem Cells
Randomised comparison of G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow-mononuclear cells for the treatment of patients with lower limb arteriosclerosis obliterans. Thromb Haemost. 2007 Dec;98(6):1335-42. doi: 10.1160/th07-02-0137
Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes. Diabetes Care. 2005 Sep;28(9):2155-60. doi: 10.2337/diacare.28.9.2155
Autologous transplantation of peripheral blood stem cells as an effective therapeutic approach for severe arteriosclerosis obliterans of lower extremities. Thromb Haemost. 2004 Mar;91(3):606-9. doi: 10.1160/TH03-06-0343
Transplantation of autologous peripheral blood stem cells for the treatment of lower limb arteriosclerosis obliterans. Chin J Hematol, 2003 Jun;24(6):308-11